Linear 1 3-diarylpropanoids
Apexbio Technology LLC AKT inhibitor VIII(Synonyms: AKTi-1/2, Akt Inhibitor VIII, AKTi VIII, Akt kinase inhibitor VIII, Isozyme-selective AKT inhibitor VIII), 10mM (in 1mL DMSO), CAS: 612847-09-3.
AKT inhibitor VIII (CAS 612847-09-3) is a cell-permeable reversible inhibitor targeting Akt isoforms Akt1 Akt2 and Akt3 exhibiting IC50 values of 58 nM 210 nM and 2119 nM respectively It acts by suppressing Akt signaling as demonstrated by its ability to inhibit IGF-1-stimulated Akt phosphorylation and to reduce PRAS40 phosphorylation in PC12 cells In MCF-7 breast cancer cells AKT inhibitor VIII enhances the antiproliferative activity of furanodiene augmenting its effects on Akt/p-Akt downregulation and promoting PARP cleavage This compound is valuable for exploring Akt-dependent signaling pathways in oncology research and neuronal cell biology studies
Medchemexpress LLC 4'-Methoxychalcone | 959-23-9 | 99.8% | 50 G
4'-Methoxychalcone is a compound that regulates adipocyte differentiation through PPARγ activation. It modulates the expression and secretion of various adipokines in adipose tissue, which are involved in insulin sensitivity.
- Regulates adipocyte differentiation via PPARγ activation.
- Modulates adipokine expression and secretion.
- Increases mRNA expression of adipogenic genes during differentiation.
- Reduces upregulated mRNA expression of inflammatory markers in preadipocyte cells.
- Exhibits antiproliferative and cytotoxic activity against various human and mouse cell lines.
Apexbio Technology LLC trans-Chalcone 614-47-1 5g
trans-Chalcone (CAS 614-47-1) is a small-molecule inhibitor targeting fatty acid synthase (FAS) and -amylase It is designed to inhibit enzymatic activity thereby regulating lipid metabolism and carbohydrate processing trans-Chalcone exerts its biological activity primarily through inhibition of FAS and -amylase In cell-based studies trans-Chalcone demonstrates induction of cell cycle arrest and apoptosis in MCF-7 breast cancer cells Based on these pharmacological properties trans-Chalcone holds research potential in oncology enzymatic inhibition studies and cell-cycle regulation analysis
Sigma Aldrich Fine Chemicals Biosciences Phospho Akt pSer473 pan
The Phospho-Akt (pSer473) ELISA (Enzyme-Linked Immunosorbent Assay) kit is a very rapid convenient and sensitive assay kit that can monitor the activation or function of important biological pathways in cell lysates.
Aobchem (4-Bromophenyl)(2-nitrophenyl)sulfane | 97% | CAS 37750-38-2 | C12H8BrNO2S | 10g
(4-Bromophenyl)(2-nitrophenyl)sulfane | 97% | CAS 37750-38-2 | C12H8BrNO2S | 10g
Aobchem (4-Bromophenyl)(2-nitrophenyl)sulfane | 97% | CAS 37750-38-2 | C12H8BrNO2S | 25g
(4-Bromophenyl)(2-nitrophenyl)sulfane | 97% | CAS 37750-38-2 | C12H8BrNO2S | 25g
Aobchem 3-Chloro-4-fluoro-5-hydroxyphenylboronic acid | ≥95% | CAS 1379466-81-5 | C6H5BClFO3 | 1g
3-Chloro-4-fluoro-5-hydroxyphenylboronic acid | ≥95% | CAS 1379466-81-5 | C6H5BClFO3 | 1g
Medchemexpress LLC Dibenzoylmethane | 120-46-7 | 98.0% | 224.26 | 10 G
Dibenzoylmethane is an analytical standard that functions as a Keap1-Nrf2 activator. A minor ingredient found in licorice, it is known to activate Nrf2, preventing various cancers and oxidative damage. As an analog of curcumin, Dibenzoylmethane facilitates the dissociation from Keap1 and promotes the nuclear translocation of Nrf2. It is provided as an off-white to light yellow solid and is intended for research and analytical applications.
- Activates Nrf2
- Prevents various cancers and oxidative damage
- Analog of curcumin
- Results in dissociation from Keap1
- Induces nuclear translocation of Nrf2
- Off-white to light yellow solid
- Intended for research and analytical applications
Aobchem 3-Chloro-5-fluoro-2-hydroxyphenylboronic acid | ≥97% | CAS 2121515-30-6 | C6H5BClFO3 | 1g
3-Chloro-5-fluoro-2-hydroxyphenylboronic acid | ≥97% | CAS 2121515-30-6 | C6H5BClFO3 | 1g
Medchemexpress LLC 1,7-Bis(4-hydroxyphenyl)-1,4,6-heptatrien-3-one | 149732-52-5 | 292.33 | 1 MG
This product is 1,7-Bis(4-hydroxyphenyl)-1,4,6-heptatrien-3-one, a potent nucleocapsid (N) protein inhibitor derived from *Curcuma kwangsiensis*. It demonstrates significant antiviral activity, particularly against HCoV-OC43 and SARS-CoV-2.
- Potent nucleocapsid protein inhibitor
- Isolated from *Curcuma kwangsiensis*
- Exhibits excellent antiviral activity against HCoV-OC43
- Shows strong antiviral activity against SARS-CoV-2
- Ideal for antiviral research and related applications